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  • Taizhou Volsen Chemical Co., Ltd.

  •  [Zhejiang,China]
  • Business Type:Manufacturer
  • Main Mark: Americas , Asia , East Europe , Europe , North Europe , Other Markets , West Europe , Worldwide
  • Exporter:91% - 100%
  • Certs:GS, CE, ISO9001, ISO14000
  • Description:185104-11-4,CAS 185104-11-4,CAS Number 185104-11-4
Taizhou Volsen Chemical Co., Ltd. 185104-11-4,CAS 185104-11-4,CAS Number 185104-11-4
Home > Products > Active Pharmaceutical Ingredients > Acotiamide Hydrochloride For Gastric Motility Improvement CAS 185104-11-4

Acotiamide Hydrochloride For Gastric Motility Improvement CAS 185104-11-4

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    Unit Price: USD 100 - 95 / Kilogram
    Payment Type: L/C,T/T,Western Union
    Incoterm: CIF
    Min. Order: 1 Kilogram
    Delivery Time: 15 Days

Basic Info

Model No.: 185104-11-4

Additional Info

Packaging: 25KGS/DRUM

Productivity: 40T/Y

Brand: VOLSENCHEM

Transportation: Ocean,Land,Air

Place of Origin: CHINA

Product Description

AcotiaMide Hydrochloride CAS number is 185104-11-4, which is a new muscarinic M1, M2 antagonist and adenosine A1 receptor antagonist, clinically isused to improve gastric motility and treat functional dyspepsia. AcotiaMide Hydrochloride is different from the general gastrointestinal motility drugs such as itopride, mosapride, it can promote the release of acetylcholine in the endogenous cholinergic nerve endings to improve gastrointestinal motility, as the first drug to improve gastrointestinal motility. Because of the hygroscopicity of acotiamide hydrochloride, its stability is poor. Under the conditions of high temperature and high humidity, the related substances greatly increase and are easy to crystallize, thereby affecting the stability of the preparation. Therefore, the preparation of AcotiaMide Hydrochloride formulation,, composition selection and dosage becomes even more important. The free choose of formulation of its ingredients may also make the dissolution of AcotiaMide Hydrochloride capsules worse, the related substances increased, the water content increased, and even unable to granulation. The traditional technical scheme adopts the wet granulation process to prepare the tablet cores and carries out the coating. In order to avoid the defect of wet granulation, some people use powder direct compression process to ensure its stability, but after a large number of experiments found that with this prescription and process Preparation of large differences in the amount of dosage, low dissolution, severe hygroscopic, a great impact on product quality.
In view of the existing shortcomings of AcotiaMide Hydrochloride CAS number is 185104-11-4, like capsule poor mobility, low dissolution, poor stability and other shortcomings, after a long-term in-depth study of the experimenter, considered the impact of various components, optimized the composition formula of AcotiaMide Hydrochloride capsules, choose acotiamide hydrochloride, microcrystalline cellulose, starch, tyrosine, sodium alginate, glyceryl behenate prepared acotiamide hydrochloride capsules, the synergistic interaction of the composition, not only to make AcotiaMide Hydrochloride capsules with good fluidity of the test , small differences in loading capacity, high dissolution, hygroscopicity was significantly reduced, good stability also improves the efficacy, greatly improving the safety and effectiveness of the drug.

Thera. Category: GASTROINTESTINAL DRUGS

Cas No.:185104-11-4

SynonymN-[2-[Bis(1-methylethyl)amino]ethyl]-2-[(2-hydroxy-4,5-dimethoxybenzoyl)amino]-4-thiazolecarboxamide hydrochloride;N-[2-[Bisisopropylamino]-ethyl]-2-[(2-hydroxy-4,5-dimethoxybenzoyl)amino]-4-thiazolecarboxamide HCl;:Acotiamide hydrochloride;

Molecular Structure: 185104-11-4

Molecular Formula:C21H30N4O5S.HCl

Molecular Weight:487.01264

Pharmacopeia: In house Spec.

Specifications:Available on request

Packing:Export worthy packing

Material Safety Data Sheet:Available on request


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Product Categories : Active Pharmaceutical Ingredients

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