Company Details
  • Taizhou Volsen Chemical Co., Ltd.

  •  [Zhejiang,China]
  • Business Type:Manufacturer
  • Main Mark: Americas , Asia , East Europe , Europe , North Europe , Other Markets , West Europe , Worldwide
  • Exporter:91% - 100%
  • Certs:GS, CE, ISO9001, ISO14000
  • Description:GMP Product Fasudil Hydrochloride 105628-07-7,Fasudil Hcl Named HA-1077 CAS 105628-07-7,High Purity Fasudil Hydrochloride 105628-07-7
Taizhou Volsen Chemical Co., Ltd. GMP Product Fasudil Hydrochloride 105628-07-7,Fasudil Hcl Named HA-1077 CAS 105628-07-7,High Purity Fasudil Hydrochloride 105628-07-7
Home > Products > Active Pharmaceutical Ingredients > Selective ROCK Inhibitor Fasudil Hydrochloride 105628-07-7

Selective ROCK Inhibitor Fasudil Hydrochloride 105628-07-7

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    Payment Type: T/T
    Incoterm: CIF
    Min. Order: 1 Kilogram
    Delivery Time: 15 Days

Basic Info

Model No.:  105628-07-7

Additional Info

Packaging: AS REQUIRED

Productivity: KGS

Brand: VOLSENCHEM

Transportation: Air

Place of Origin: CHINA

Supply Ability: TRUE MANUFACTURER

Certificate: ISO

Product Description

Fasudil hydrochloride CAS number is 105628-07-7, a RHO kinase inhibitor and a novel intracellular Ca2+ antagonist. It expands blood vessels by increasing the activity of myosin light chain phosphatase, reduces the tension of endothelial cells, improves brain microcirculation, protects ischemic brain tissue, and at the same time antagonizes inflammatory factors, protects nerves against apoptosis, and promotes nerve regeneration. Clinically, it is mainly used to prevent and improve vasospasm caused by various causes, selectively dilate sputum blood vessels, and improve heart and cerebral ischemia. Studies have shown that fasudil hydrochloride CAS 105628-07-7 has certain side effects, common headaches, occasional liver damage, intracranial hemorrhage and hypotension.
Fasudil hydrochloride injection is a commonly used preparation form, which has the advantages of low cost and convenient use. However, fasudil hydrochloride is extremely sensitive to light and easily resolves insoluble particles. The potential degradation mode is that 5-isoquinoline sulfonic acid and homopiperazine dissociate and degrade under illumination to produce impurity isoquinoline-5. - Sulfonic acid, in addition, the dissociated piperazine and homopiperazine structures are easily oxidized to produce an oxidation product. Therefore, fasudil hydrochloride injection is very strict in storage and protection from light. It is often encapsulated in a brown ampoule, which not only increases the cost but also affects the effect of the lamp inspection. In addition, its light sensitivity to the injection solution is inconvenient to use, save and transport. Therefore, it is necessary to strengthen the storage management of the light stability of fasudil hydrochloride injection.

Thera. Category:Cardiovascular and Cerebrovascular Diseases Treatment

Cas No.: 105628-07-7

105628-07-7

Synonym:HEXAHYDRO-1-(5-ISOQUINOLINYLSULFONYL)-MONOHYDROCHLORIDE;HA-1077;HA-1077 DIHYDROCHLORIDE;FASUDEL;FASUDIL DIHYDROCHLORIDE;1-(5-ISOQUINOLINESULFONYL)HOMOPIPERAZINE HYDROCHLORIDE;(5-ISOQUINOLINESULFONYL)HOMOPIPERAZINE, 2HCL;5-(1,4-DIAZEPAN-1-YLSULFONYL)ISOQUINOLINE HYDROCHLORIDE;

Molecular Formula:C14H18ClN3O2S

Molecular Weight:327.83

Assay: ≥99.%

Packing: Export worthy packing

lMaterial Safety Data Sheet: Available on request


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Product Categories : Active Pharmaceutical Ingredients

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