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  • Taizhou Volsen Chemical Co., Ltd.

  •  [Zhejiang,China]
  • Business Type:Manufacturer
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  • Exporter:91% - 100%
  • Certs:GS, CE, ISO9001, ISO14000
  • Description:Intermediate of Brexpiprazole 66490-33-3,CAS 66490-33-3,CAS Number 66490-33-3
Taizhou Volsen Chemical Co., Ltd. Intermediate of Brexpiprazole 66490-33-3,CAS 66490-33-3,CAS Number 66490-33-3
Home > Products > Pharmaceutical Intermediates > Anti-Psychotics > 4-Chloro-Benzo[b]thiophene For Making Brexpiprazole CAS 66490-33-3

4-Chloro-Benzo[b]thiophene For Making Brexpiprazole CAS 66490-33-3

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    Unit Price: USD 1 / Kilogram
    Incoterm: CIF
    Min. Order: 1 Kilogram
    Delivery Time: 15 Days

Basic Info

Model No.: 66490-33-3

Additional Info

Packaging: As required

Productivity: 10KG/M

Brand: VOLSENCHEM

Transportation: Air

Place of Origin: CHINA

Certificate: Technical Support

Product Description

4-chloro- Benzo[b]thiophene is intermediate of brexpiprazole CAS number 66490-33-3. We can also provide another compounds in the form of bromine. It is the primary intermediate of brexpiprazole, mainly for the synthesis of brexpiprazole high-level intermediate of 1 - (benzo [b] thiophen-7-yl) piperazine hydrochloride, we will referred it as piperazine hydrochloride salt. The conventional synthesis method is directly reacted 4-chlorobenzo [b] thiophene with piperazine to obtain piperazine hydrochloride, but since the substitution reaction is insufficient in the case where the chlorine atom in the 4-chlorobenzo [b] thiophene is not actively, easy to cause excessive impurities, which brings some difficulties to the post-processing and purification. So this method is not ideal. There is also a method in which put anhydrous piperazine reacted with BOC anhydride in methylene chloride to give N-BOC-piperazine and then coupled with 4-chlorobenzo [b] thiophene in the presence of catalyst BINAP and palladium acetate to give the corresponding compound and then react with concentrated hydrochloric acid to give the target compound piperazine hydrochloride CAS number 66490-33-3.


Thera. Category:Anti- Psychotics

Cas No.:66490-33-3

Synonyms: 4-chloro- Benzo[b]thiophene;Benzo[b]thiophene, 4-chloro-;4-Chlorobenzothiophene;Intermediate of Brexpiprazole

NW: 168.6433

M.W.: C8H5ClS

66490-33-3

Assay: ≥99%

Packing:Export worthy packing

Material Safety Data Sheet:Available on request

Usage: Intermediate of Brexpiprazole

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Product Categories : Pharmaceutical Intermediates > Anti-Psychotics

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  • 4-Chloro-Benzo[b]thiophene For Making Brexpiprazole CAS 66490-33-3
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