Company Details
  • Taizhou Volsen Chemical Co., Ltd.

  •  [Zhejiang,China]
  • Business Type:Manufacturer
  • Main Mark: Americas , Asia , East Europe , Europe , North Europe , Other Markets , West Europe , Worldwide
  • Exporter:91% - 100%
  • Certs:GS, CE, ISO9001, ISO14000
  • Description:Idelalisib Intermediate 870281-86-0,Idelalisib Intermediate CAS 870281-86-0,Intermediate of Idelalisib Intermediate
Taizhou Volsen Chemical Co., Ltd. Idelalisib Intermediate 870281-86-0,Idelalisib Intermediate CAS 870281-86-0,Intermediate of Idelalisib Intermediate
Home > Products > Contract Manufacturing > High Quality and Favorable Price Idelalisib intermediate 870281-86-0

High Quality and Favorable Price Idelalisib intermediate 870281-86-0

Share to:  
    Unit Price: USD 1 / Kilogram
    Payment Type: T/T
    Incoterm: CIF
    Min. Order: 1 Kilogram
    Delivery Time: 15 Days

Basic Info

Model No.: 870281-86-0

Additional Info

Packaging: As Quantity

Productivity: As Order

Brand: VOLSENCHEM

Transportation: Air

Place of Origin: CHINA

Product Description

Our company is a leading global supplier of Idelalisib Intermediate CAS 870281-86-0. Idelalisib Intermediate 870281-86-0 is widely used in chronic lymphocytic leukemia. Idelalisib Intermediate CAS NO 870281-86-0 is assured to manufacture from industry approved high quality raw materials, and we can give a favorable price to you.

Thera. Category:

Cas No.:870281-86-0

Synonyms:(S)-2-(1-aMinopropyl)-5-fluoro-3-phenylquinazolin-4(3H)-one;2-[(1S)-1-Aminopropyl]-5-fluoro-3-phenyl-4(3H)-quinazolinone;Idelalisib INT;CAL-101(N-1);CAL101(N-1);CAL 101(N-1);

MF:C17H16FN3O

NW:297.3268432

870281-86-0

Assay: ≥99%

Packing:Export worthy packing

Material Safety Data Sheet:Available on request

Usage:CAL-101 (Idelalisib, GS-1101) is a selective p110δ inhibitor; shown to have 40- to 300-fold greater selectivity for p110δ than p110α/β/γ, and 400- to 4000-fold more selectivity to p110δ than C2β, hVPS34, DNA-PK and mTOR. Henan CoreyChem can supply the intermediate of CAL101 and also research the synthesis route of CAL101

CAL-101 (Idelalisib, GS-1101) is a selective p110δ inhibitor with IC50 of 2.5 nM; shown to have 40- to 300-fold greater selectivity for p110δ than p110α/β/γ, and 400- to 4000-fold more selectivity to p110δ than C2β, hVPS34, DNA-PK and mTOR.
IC50 value: 2.5 nM [1]
Target: p110δ
in vitro: CAL-101 is not sensitive to other PI3K class I subunits including p110α, p110β, and p110γ. CAL-101 specifically blocks Fc?R1 p110δ-mediated CD63 expression with an EC50 of 8 nM in primary basophil. CAL-101 exhibits greater activity in B-cell acute lymphoblastic leukemia (B-ALL) and chronic lymphocytic leukemia (CLL) cells compared with acute myeloid leukemia (AML) and myeloproliferative neoplasm (MPN) cells. CAL-101 produces the reduction in pAktS473, pAktT308, and the downstream target S6 in SU-DHL-5, KARPAS-422 and CCRF-SB cells with EC50 of 0.1 to 1.0 μM [1]. CAL-101 induces selective cytotoxicity in CLL cells independent of IgVH mutational status or interphase cytogenetics, primarily through a caspase-dependent mechanism. CAL-101 induces cytotoxicity preferentially to CLL cells compared with normal B cells, without producing cytotoxicity in other hematopoietic cells, compared to LY294002. CAL-101 lacks direct cytotoxic potential to T cells and nature killer (NK) cells. CAL-101 can inhibit production of inflammatory cytokines, such as IL-6, IL-10, TNF-α, and IFN-γ, and activation-induced cytokines, such as CD40L. CAL-101 also antagonizes CD40L-mediated CLL cell survival [2]. AL-101 induces an accumulation of cells in G1 and a decrease in the S-phase population in L1236 and L591 cells, which indicates CAL-101 as a novel strategy for the treatment of hodgkin lymphoma (HL) [3].

We are availabe for several related Intermediates

1) CAS 385-02-4,2-Fluoro-6-nitrobenzoic acid

2) CAS 870281-83-7,2-Fluoro-6-nitro-N-phenylbenzamide

3) CAS 870281-84-8,(S)-([1-(2-fluoro-6-nitro-benzoyl)-phenyl-aMinocarbonyl]-propyl)-carbaMic acid tert-butyl ester

4) CAS 870281-85-9,(S)-tert-butyl (1-(5-fluoro-4-oxo-3-phenyl-3,4-dihydroquinazolin-2-yl)propyl)carbaMate

5) CAS 870281-86-0,(S)-2-(1-aMinopropyl)-5-fluoro-3-phenylquinazolin-4(3H)-one

6) CAS 870281-82-6,CAL-101

7) CAS 767-69-1,6-Bromopurine

Looking for ideal Idelalisib Intermediate 870281-86-0 Manufacturer & supplier ? We have a wide selection at great prices to help you get creative. All the Idelalisib Intermediate CAS 870281-86-0 are quality guaranteed. We are China Origin Factory of Intermediate of Idelalisib Intermediate. If you have any question, please feel free to contact us.

Product Categories : Contract Manufacturing

Product Images
  • High Quality and Favorable Price Idelalisib intermediate 870281-86-0
Email to this supplier
  • *Subject:
  • *Messages:
    Your message must be between 20-8000 characters
Copyright © 2018 Taizhou Volsen Chemical Co., Ltd. All rights reserved.
Communicate with Supplier?Supplier
Amy Cheng Ms. Amy Cheng
What can I do for you?