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HomeProductsPharmaceutical IntermediatesAnti-Psychotics1-Bromo-3,5-Dimethyladamantane Used for Memantine CAS 941-37-7
1-Bromo-3,5-Dimethyladamantane Used for Memantine CAS 941-37-7
  • 1-Bromo-3,5-Dimethyladamantane Used for Memantine CAS 941-37-7

1-Bromo-3,5-Dimethyladamantane Used for Memantine CAS 941-37-7

    Unit Price: USD 1 / Kilogram
    Incoterm: CIF
    Min. Order: 1 Kilogram
    Delivery Time: 15 Days

Basic Info

Model No.: 941-37-7

Additional Info

Packaging: As required

Productivity: Commercial


Transportation: Air

Place of Origin: CHINA

Certificate: Technical Support

Product Description

1-Bromo-3,5-dimethyladamantane is intermediate 2 of Memantine hydrochloride, CAS number is 941-37-7, usually it is brominated from 1,3-dimethyladamantane. Researchers adjusted conventional synthetic methods through experiment. The specific experimental operation is as following, take 200gram 1,3 - dimethyladamantane, placed in three bottles, then connect drying tube and exhaust gas absorption device. Heated to 75 ° C, drop 190 ml of bromine, reacted for 26 hours, and cooled to room temperature. Add 400ml methylene chloride,cooling by ice bath, add saturated sodium bisulfite solution to the mixture into a pale yellow solution. Static stratification, divided organic phase. The aqueous phase was extracted with methylene chloride and combined organic phases, washed with saturated sodium carbonate solution till neutral,then washed with saturated sodium chloride solution. Then the organic phase was dried over anhydrous sodium sulfate, concentrated under reduced pressure and the fraction was collected at 80 ° C to get 275gram colorless transparent liquid, the yield is more than 92%. His preparation process is relatively simple, and then further synthesis of the preparation of its next step is the most difficult on process of the memantine hcl. The conventional practice is take reaction metamorphine hydrochloride intermediate 2 with nitriles and concentrated sulfuric acid, but the resulting mixture is very viscous and it is very difficult to stir at the post-reaction stage, resulting in a low yield. We believe that this method should be adjusted to take reaction the memantine hydrochloride 2 CAS number 941-37-7 and nitrile, concentrated sulfuric acid and organic acid , after the end of the reaction,pour into the water. This method not only solves the problem of agitation difficult, but also greatly simplifies the post-reaction operation.

Thera. Category: Parkinsonism Alzheimers Disease Treatment

Cas No.:941-37-7

Synonyms: 1-BROMO-3,5- DIMETHYL DAMANTANE;1,3-Dimethyl-5-bromoadamantane;tricyclo[,7~]decane, 1-bromo-3,5-dimethyl-;NSC 102293;1-Bromo-3,5-dimethyltricyclo[,7]decane;1-BROMO-3,5-DIMETHYLADAMANTANE;3,5-dimethyl-1-bromo- adamantane;1-Bromo-3,5-Dimethyl;

NW: 243.18

M.W.: C12H19Br


Assay: ≥99%

Packing:Export worthy packing

Material Safety Data Sheet:Available on request

Usage: Intermediate of Memantine

1)1,3-dimethyladamantane CAS number 702-79-4

2) 1-Bromo-3,5-dimethyladamantane CAS number 941-37-7

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Product Categories : Pharmaceutical Intermediates > Anti-Psychotics

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