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"Nature": Changing a gene can extend life expectancy by 30, Human breakthrough 120 years will become a reality

On December 11, researchers from the Sanford Burnham Prebys Medical Research Institute in the United States published a research paper in the international top journal "Nature", saying that as long as the expression of the P62 gene, which is ubiquitous in the body, can be extended by 20% -30%. The discovery may help uncover the secrets of human longevity and help humans find treatments for aging-related diseases.

The research team revealed that many studies have shown that cells can extend their life span by enhancing autophagy degradation to recover old, broken and damaged proteins. Autophagy has a strong selectivity, which means that the cells will also adopt a similar method Ways to recycle waste, different types of waste can be transported to the cell's "recycling center". The study found that the P62 gene can transport damaged mitochondria to a recycling center, so the P62 gene is a key substance that affects the life of the organism.

The study proved that aging and longevity are closely related to cellular mitochondrial damage. Earlier, scientists gradually realized that the operation of the mitochondrial repair system is closely related to the activity of a long-lived protein family called Sirtuins. Since 2014, David Sinclair's laboratory, a professor of genetics at Harvard Medical School, has further confirmed that the activity of the Sirtuins protein family is closely related to a coenzyme NAD + in the body.NAD + is both an important raw material for the DNA repair system and a key contact factor between the nucleus and the mitochondria.

Therefore, by increasing the level of NAD + in the cell to maintain the repair ability of mitochondrial DNA, mitochondrial damage caused by aging can be effectively repaired, which is considered to be a key way to inhibit aging and extend life.

In the next few years, Sinclair and Shinichiro Imai's laboratory at the University of Washington independently independently confirmed the ingestion of a naturally occurring NAD + precursor substance BETA-NICOTINAMIDE MONONUCLEOTIDE (NMN, a popular rich man's "longevity" The main ingredient of the drug "Reinvigorator" )can effectively increase the content of NAD + in various organs of the body, thereby improving the DNA repair ability of cells such as mitochondria, and reverse muscle atrophy, improve physical performance, and inhibit cognitive decline caused by aging; Vascular death, protection of cardio-cerebral vascular function, and other aspects have significant anti-aging effects. This is consistent with the core mechanism of altering P62 gene expression and extending lifespan.

In the following years, β- NICOTINAMIDE MONONUCLEOTIDE quickly became the focus of research in the field of aging medicine. Harvard University, MIT, Washington University, Keio University and other international top institutions published in Nature, Science, and Cell Nearly a hundred papers of authoritative academic journals such ashave detailed its efficacy and mechanism of action.And it was confirmed that the increase in NAD + caused by oral BETA-NICOTINAMIDE MONONUCLEOTIDE can extend the life of experimental animals similar to humans by more than 30%. So far, BETA-NICOTINAMIDE MONONUCLEOTIDE has been officially recognized as the world's first scientific research result that has been proven by rigorous scientific experiments to effectively reverse and delay aging and prolong life.

Before the introduction of Reinvigorator,BETA-NICOTINAMIDE MONONUCLEOTIDE had been chased by very few wealthy and technical elites who longed for longevity. They heard the wind and tried every means to obtain a small amount of BETA-NICOTINAMIDE MONONUCLEOTIDE from the laboratory through various channels. Nucleotides are for oral consumption. Trump's technology adviser, Silicon Valley venture capitalist, and author of "From 0 to 1" Peter Thiel publicly announced that he would eat a aging inhibitor similar to Reinvigorator almost every day; Bill Gates, the world's richest man, was in an Internet user interaction It has been suggested that many wealthy friends around him are already [artificially prolonging life" by taking products similar to Reinvigoratorβ-NICOTINAMIDE MONONUCLEOTIDE products, and they will consider it themselves; the richest man in China, Li Jiacheng, is taking the previous generation of the product said "feeling 20 years younger" five months later, and immediately decided to invest 25 million Hong Kong dollars to invest in the manufacturer.

However, sinceNICOTINAMIDE MONONUCLEOTIDE (the main component of Reinvigorator) were only sold to research institutions as scientific research materials, even if calculated based on the lowest effective dose, the annual cost per person would be as high as 1.56 million yuan. Therefore, β-nicotinamide mononucleotide has become the exclusive benefit of a few of the world's top wealthy and scientists involved in related research, and its road to mass production has been long and arduous. In 2016, Japan's emerging and company took the lead in realizing β-nicotinamide single nucleotide production, but its market price was 20,000 yuan / bottle. In 2018, Herbalmax in the United States reduced the price of β-nicotinamide single nucleotides by more than 90% through advanced enzyme catalysis technology (the pricing of Jingdong, Suning, and Tmall is less than 2,000 yuan), the world's first mature β-nicotinamide single Only Reinvigorator, a nucleotide product, was released. At the end of the same year, after being introduced to China by cross-border e-commerce platforms such as Jingdong Tmall and Suning, Ruiweituo suffered a rush after it was put on the market.

With the launch of Reinvigorator, the academic community's research on β-nicotinamide single nucleotides has further heated up. As soon as Rui Wei Tuo went public and was sought after by the wealthy circles, research in the biological sciences academic community continued to advance. In June this year, research results published by the research team of the University of Washington School of Medicine in the journal Cell Metabolism showed that β-nicotinamide single nucleotide expression was increased in mice by injection, leaving the average remaining life length only Two months (equivalent to 6 years in humans) the life length of elderly experimental mice was extended to 4.6 months (that is, 13.8 years in humans), and the remaining life length was doubled.

In August 2019, scientists at the Reynolds Geriatrics Research Center in Oklahoma, United States further confirmed:

Supplementation of β-nicotinamide mononucleotide to elderly mice can enhance the biosynthesis of NAD + in the body, which can reverse age-related dysfunction of multiple organs including eyes, skeletal muscle and peripheral arteries, and improve and prolong The role of healthy life in aging mice. β-nicotinamide mononucleotide has potential use in the treatment of vascular cognitive impairment caused by aging, and β-nicotinamide single nucleotide-modulated NAD + biosynthetic anti-aging mechanism can be used to develop new drugs To prevent and treat age-related aging diseases.

In 1961, American scientist Helfrey proposed that human cells will aging and die when they divide to 50 times, and the cycle of normal cell division is about 2.4 years / time. According to this calculation, the life limit of a person is 120 years. . This is the famous "Helfrey Limit". The iteration of life technology has led people to believe that through artificial interventions such as changing the expression of P62 gene, cell division can be changed, and human life span exceeds the limit of 120 years in Helfrey. By then, everyone's life expectancy will exceed 100 years will become a reality.

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