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  • Taizhou Volsen Chemical Co., Ltd.

  •  [Zhejiang,China]
  • Business Type:Manufacturer
  • Main Mark: Americas , Asia , East Europe , Europe , North Europe , Other Markets , West Europe , Worldwide
  • Exporter:91% - 100%
  • Certs:GS, CE, ISO9001, ISO14000
  • Description:870281-82-6,CAS 870281-82-6,Idelalisib CAL-101 for Inhibitor
Taizhou Volsen Chemical Co., Ltd. 870281-82-6,CAS 870281-82-6,Idelalisib CAL-101 for Inhibitor
Home > Products > Contract Manufacturing > CAS 870281-82-6,CAL-101(Idelalisib, GS-1101)

CAS 870281-82-6,CAL-101(Idelalisib, GS-1101)

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    Unit Price: USD 1 / Kilogram
    Payment Type: T/T
    Incoterm: CIF
    Min. Order: 1 Kilogram
    Delivery Time: 15 Days

Basic Info

Model No.: 870281-82-6

Additional Info

Packaging: As Quantity

Productivity: As Order

Brand: VOLSENCHEM

Transportation: Air

Place of Origin: CHINA

Product Description

Catering to the plethora of needs of our diverse client base we are prominent providers of highly effective Idelalisib(CAL-101) CAS 870281-82-6. Idelalisib(CAL-101) CAS NO 870281-82-6,supplied by us, is high quality, safe, reliable. The purity of Idelalisib(CAL-101) 870281-82-6 is more than 99%. Skilled quality controllers use innovative testing techniques and measures to ensure all the products to be of the finest possible quality.

Thera. Category: PI3K delta inhibitor

Cas No.: 870281-82-6

Synonyms: CAL-101;GS1101;CAL-101 (GS-1101);5-Fluoro-3-phenyl-2-[(1S)-1-(9H-purin-6-ylamino)propyl]-4(3H)-quinazolinone;CAL101,CAL 101;CAL-101;CAL-101 (Idelalisib, GS-1101);(S)-2-(1-((9H-Purin-6-yl)aMino)propyl)-5-fluoro-3-phenylquinazolin-4(3H)-one;Idelalisib(CAL-101)

MF: C22H18FN7O

NW: 415.4230232

870281-82-6

Assay: ≥99%

Packing: Export worthy packing

Material Safety Data Sheet: Available on request

CAL-101 (Idelalisib, GS-1101) is a selective p110δ inhibitor with IC50 of 2.5 nM; shown to have 40- to 300-fold greater selectivity for p110δ than p110α/β/γ, and 400- to 4000-fold more selectivity to p110δ than C2β, hVPS34, DNA-PK and mTOR.
IC50 value: 2.5 nM [1]
Target: p110δ
in vitro: CAL-101 is not sensitive to other PI3K class I subunits including p110α, p110β, and p110γ. CAL-101 specifically blocks Fc?R1 p110δ-mediated CD63 expression with an EC50 of 8 nM in primary basophil. CAL-101 exhibits greater activity in B-cell acute lymphoblastic leukemia (B-ALL) and chronic lymphocytic leukemia (CLL) cells compared with acute myeloid leukemia (AML) and myeloproliferative neoplasm (MPN) cells. CAL-101 produces the reduction in pAktS473, pAktT308, and the downstream target S6 in SU-DHL-5, KARPAS-422 and CCRF-SB cells with EC50 of 0.1 to 1.0 μM [1]. CAL-101 induces selective cytotoxicity in CLL cells independent of IgVH mutational status or interphase cytogenetics, primarily through a caspase-dependent mechanism. CAL-101 induces cytotoxicity preferentially to CLL cells compared with normal B cells, without producing cytotoxicity in other hematopoietic cells, compared to LY294002. CAL-101 lacks direct cytotoxic potential to T cells and nature killer (NK) cells. CAL-101 can inhibit production of inflammatory cytokines, such as IL-6, IL-10, TNF-α, and IFN-γ, and activation-induced cytokines, such as CD40L. CAL-101 also antagonizes CD40L-mediated CLL cell survival [2]. AL-101 induces an accumulation of cells in G1 and a decrease in the S-phase population in L1236 and L591 cells, which indicates CAL-101 as a novel strategy for the treatment of hodgkin lymphoma (HL) [3].

We are availabe for several related Intermediates

1) CAS 385-02-4,2-Fluoro-6-nitrobenzoic acid

2) CAS 870281-83-7,2-Fluoro-6-nitro-N-phenylbenzamide

3) CAS 870281-84-8,(S)-([1-(2-fluoro-6-nitro-benzoyl)-phenyl-aMinocarbonyl]-propyl)-carbaMic acid tert-butyl ester

4) CAS 870281-85-9,(S)-tert-butyl (1-(5-fluoro-4-oxo-3-phenyl-3,4-dihydroquinazolin-2-yl)propyl)carbaMate

5) CAS 870281-86-0,(S)-2-(1-aMinopropyl)-5-fluoro-3-phenylquinazolin-4(3H)-one

6) CAS 870281-82-6,CAL-101

7) CAS 767-69-1,6-Bromopurine


8) N,N'-Bis-(2-Chloroethyl)urea CAS 2214-72-4


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