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  • Taizhou Volsen Chemical Co., Ltd.

  •  [Zhejiang,China]
  • Business Type:Manufacturer
  • Main Mark: Americas , Asia , East Europe , Europe , North Europe , Other Markets , West Europe , Worldwide
  • Exporter:91% - 100%
  • Certs:GS, CE, ISO9001, ISO14000
  • Description:High Purity Isoprenaline Impurity A CAS 16899-81-3,Isoproterenol Intermediate 16899-81-3,CAS 16899-81-3
Taizhou Volsen Chemical Co., Ltd. High Purity Isoprenaline Impurity A CAS 16899-81-3,Isoproterenol Intermediate 16899-81-3,CAS 16899-81-3
Home > Products > Contract Manufacturing > 1-(3,4-Dihydroxyphenyl)-2-[(1-Methylethyl)amino] Hydrochloride CAS 16899-81-3

1-(3,4-Dihydroxyphenyl)-2-[(1-Methylethyl)amino] Hydrochloride CAS 16899-81-3

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    Unit Price: USD 1 / Kilogram
    Incoterm: CIF
    Min. Order: 1 Kilogram
    Delivery Time: 15 Days

Basic Info

Model No.: 16899-81-3

Additional Info

Packaging: As required

Productivity: 10KG/M


Transportation: Air

Place of Origin: CHINA

Certificate: Technical Support

Product Description

1-(3,4-Dihydroxyphenyl)-2-[(1-Methylethyl)amino] Hydrochloride CAS 16899-81-3, also known as Isoprenaline Impurity A is white powder with the molecular formula of C11H15NO3.ClH and formula weight of 245.704. 1-(3,4-Dihydroxyphenyl)-2-[(1-Methylethyl)amino] Hydrochloride CAS NO 16899-81-3 is widely used to synthesis Isoprenaline that as a medication used for the treatment of bradycardia (slow heart rate), heart block, and rarely for asthma. We have certain inventory to meet the emergency requirements of the customers.

At present, the production of Isoproterenol ketone hydrochloride mostly take the following route, The catechol and monochloroacetic acid in the role of phosphorus oxychloride by Friedel–Crafts reaction to obtain chloroacetyl catechol, and then react with isopropylamine, And finally through hydrogen chloride to get Isoproterenol ketone hydrochloride. If you want to further synthesis of its final drug, but also in the role of palladium on the catalytic hydrogenation reduction. This route has two shortcomings: First, the first step of the reaction used by the chloroacetic acid and phosphorus oxychloride has corrosive and harmful to the human body, the phosphorus-containing wastewater is also extremely difficult to deal after the reaction.. Second, the Friedel reaction yield is low, and the reaction process is very easy to stick, resulting occur in spray phenomenon.. Based on the above shortcomings, some people adjust the line, roughly as following, catechol and glycine in the role of zinc chloride by Friedel Crafts reaction noradrenalone, then add 2-chloropropane, and And finally through hydrogen chloride to get Isoproterenol ketone hydrochloride. It should be noted that after the temperature reaction to cool down to room temperature in the first step , adding dilute hydrochloric acid to quench

Thera. Category: Treatment of bradycardia

Cas No.:16899-81-3

Synonyms: 1-(3,4-dihydroxyphenyl)-2-[(1-methylethyl)amino] hydrochloride;U 12844A;Ethanone,1-(3,4-dihydroxyphenyl)-2-[(1-methylethyl)amino]-, hydrochloride (1:1);1-(3,4-Dihydroxyphenyl)-2-[(1-methylethyl)amino]ethanone hydrochloride;Isoprenaline impurity A

NW: 245.704

M.W.: C11H15NO3.ClH


Assay: ≥99%

Packing:Export worthy packing

Material Safety Data Sheet:Available on request

Usage: Intermediate of Isoprenaline Intermediate

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