Jak1 Inhibitors Abrocitinib Cas No 1622902 68 4

JAK1 and JAK2 Inhibitors Momelotinib(CYT 11387,CYT-387,CYT387)1056634-68-4

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Momelotinib CAS 1056634-68-4 is an potent JAK1 and JAK2 Inhibitors acting as an ATP competitive molecule with IC50 values of 11 and 18 nM, respectively. The inhibitor is significantly less active towards other kinases, including JAK3 (IC50 = 0.16 μM). Momelotinib also named as CYT 11387,CYT-387,CYT387, CYT-387 has the...

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4-Chloro-7-((2-(Trimethylsilyl)ethoxy)Methyl)-7H-Pyrrolo[2,3-d]pyrimidine CAS 941685-26-3

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4-Chloro-7-((2-(Trimethylsilyl)ethoxy)Methyl)-7H-Pyrrolo[2,3-d]pyrimidine CAS 941685-26-3 plays an important role in synthesis Baricitinib. Baricitinib, also called LY3009104 and INCB028050, is a potent inhibitor of JAK1 and JAK2. Manufactured 2-[(4-chloropyrrolo[2,3-d]pyrimidin-7-yl)methoxy]ethyl-trimethylsilane...

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A Potent JAK1 and JAK2 Inhibitor Baricitinib CAS 1187594-09-7

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Baricitinib (olumiant) has the cas number of 1187594-09-7 is a selective JAK2 and JAK1 inhibitor that targets multiple active rheumatoid arthritis-associated cytokine pathways, thereby reducing the activation and proliferation of key immune cells in inflammatory cells. It is mainly used to treat moderate to severe...

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Synthesis JAK1 and JAK2 Inhibitor Baricitinib Intermediate CAS 1029716-44-6

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Baritinib intermediate is 1-(1-ethoxyethyl)-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazole CAS number 1029716-44-6. There are two main synthetic methods, the first one is use 4-bromo-1-(1-ethoxyethyl)-1H-pyrazole and 2-methoxy-4,4,5,5-four Methyl-1,3,2-dioxaborolan as the starting material, and the target...

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Selective JAK1 Inhibitor Filgotinib Intermediate CAS 1010120-55-4

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Thera. Category:Rheumatoid arthritis Cas No.:1010120-55-4 Synonyms:2-AMino-5-broMo-[1,2,4]triazolo[1,5-a]pyridin;5-Bromo-[1,2,4]triazolo[1,5-a]pyridin-2-ylamine Molecular Formula: C6H5BrN4 Molecular Weight: 213.03

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Abrocitinib Development Code PF-04965842 CAS NO 1622902-68-4

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. Thera. Category: Jak1 inhibitor Cas No.:1622902-68-4 Synonyms:PF-04965842 ;Abrocitinib Molecular Formula:C14H21N5O2S Molecular Weight: 323.41

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Mereletinib Mesylate AZD9291,AZD-9291 (Mesylate) 1421373-66-1

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Mereletinib mesylate cas number 1421373-66-1 is the third generation of oral, irreversible selective EGFR mutant inhibitors that can be used for activated and resistant mutations in EGFR. For patients with advanced non-small cell lung cancer, 50% of the anti-EGFR treatment acquired resistance is caused by the T790M...

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Small Molecule Inhibitors Amsacrine CAS 51264-14-3

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Amsacrine with the cas number of 51264-14-3,the Appearance is orange-red crystalline powder, it is a kind of acridine derivatives, belongs to cell inhibitor.Amsacrine is major treated for acute myeloid leukemia, may be effective in cases of anthracycline deficiency. Its anti-cancer mechanism is similar to the...

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MST1/2 Inhibitors XMU-MP-1;XMUMP1;XMU MP 1 CAS 2061980-01-4

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XMU-MP-1 CAS number is 2061980-01-4, molecular formula: C17H16N6O3S2, molecular weight: 414.777334. XMU-MP-1 is an inhibitor of MST1/2 and inhibits the IC50 of MST1 and MST2 of 71.1 ± 12.9 nM and 38.1 ± 6.9 nM, respectively. XMU-MP-1 inhibits MST1/2 activity and thus activates the downstream effector molecule Yap...

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PARP Inhibitors Veliparib Treat For Breast Cancer CAS 912444-00-9

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Veliparib CAS number is 912444-00-9, research and development code is ABT-888, he developed the third generation of active and selective PARP inhibitors of benzimidazole structure developed by AbbVie in 2006. Mainly acts on PARP-1 and PARP-2. At present, veliparib combined with whole brain radiotherapy for metastatic...

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Bluk Production Of 3-Oxocyclobutanecarboxylic Acid CAS 23761-23-1 Used For PF04965842 Abrocitinib

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Thera. Category:Atopic dermatitis Cas No.:23761-23-1 Synonyms:3-OXO-CYCLOBUTANECARBOXYLIC ACID;(3-oxocyclobutyl)carboxylic acid;PF-04965842(Abrocitinib) intermediates Molecular Formula: C5H6O3 Molecular Weight: 114.1

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Commerical Supplying Abrocitinib Intermediate Treat For Atopic Dermatitis CAS 2204290-99-1

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. Thera. Category: Atopic dermatitis Cas No.:2204290-99-1 Synonyms: PF-04965842(Abrocitinib) intermediate;Carbamic acid, N-[cis-3-(methylamino)cyclobutyl]-, phenylmethyl ester, hydrochloride (1:1);Benzyl (cis-3-(methylamino)cyclobutyl)carbamate hydrochloride Molecular Formula:

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