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Taizhou Volsen Chemical Co., Ltd.
HomeProductsActive Pharmaceutical Ingredients4-(5-(4-(Pentyloxy)phenyl)Isoxazol-3-yl)Benzoic Acid For Micafungin Cas 179162-55-1
4-(5-(4-(Pentyloxy)phenyl)Isoxazol-3-yl)Benzoic Acid For Micafungin  Cas 179162-55-1
  • 4-(5-(4-(Pentyloxy)phenyl)Isoxazol-3-yl)Benzoic Acid For Micafungin  Cas 179162-55-1

4-(5-(4-(Pentyloxy)phenyl)Isoxazol-3-yl)Benzoic Acid For Micafungin Cas 179162-55-1

    Payment Type: L/C,T/T
    Incoterm: FOB,CFR,CIF,CPT,CIP
    Min. Order: 1 Gram
    Delivery Time: 7 Days

Basic Info

Model No.: 179162-55-1

Function: Antibiotic and Antimicrobial Agents

Additional Info

Packaging: Export worthy packing

Productivity: 50KG/Y

Brand: VOLSENCHEM

Transportation: Ocean,Air

Place of Origin: CHINA

Supply Ability: Immediately

Product Description

Micafungin side chain also as known as 4-(5-(4-(pentyloxy)phenyl)isoxazol-3-yl)benzoic acid CAS number is 179162-55-1, his synthesis process is as following:
1. 23 g of p-hydroxyacetophenone, 28 g of bromopentane, 28 g of anhydrous potassium carbonate, dissolved in 115 mL of dimethylformamide (DMF), stirred at an internal temperature of 65 to 70℃, and stirred for 4 hours. The reaction liquid was a white suspension. After completion of the reaction, the mixture was cooled to room temperature, and then 210 mL of petroleum ether and 210 mL of water were successively added, and the mixture was shaken to leave a petroleum ether layer. The petroleum ether layer was washed successively with 120 ml of 0.5 mol/L sodium hydroxide solution and 120 ml of saturated brine, and the petroleum ether was dried over anhydrous magnesium sulfate for 30 min, and the magnesium sulfate was removed by filtration, and the petroleum ether was evaporated to give a colorless oily product. As a solid, the product compound was obtained in a total of about 33 g of pentanyloxyacetophenone.
2. 8.2 g of p-pentyloxyacetophenone obtained in the first step, 8.5 g of p-hydroxybenzoic acid, 2.6 g of sodium hydroxide, dissolved in 32 ml of water and 12 ml of ethanol, and stirred at an internal temperature of 40 to 45℃ for 6 hours. . After the completion of the reaction, the reaction solution was cooled in an ice bath, and 10% dilute hydrochloric acid was added to adjust pH to 2, and a large amount of solid was precipitated in the reaction mixture, and the solid was collected by filtration. The solid was stirred at room temperature in 80 ml of ethanol, and the impurities were washed away, and filtered to give 5.3 g of a solid compound.
3. Take 1.3 g of the solid compound obtained in the step 2, 5.0 g of TsNHOH, and 1.2 g of sodium hydroxide in a solution of 20 ml of methanol:water = 9:1. The internal temperature of the reaction liquid was stirred at 40 to 45℃ for 48 hours. After the completion of the reaction, the reaction solution was added with 10% dilute hydrochloric acid under ice cooling to adjust pH = 2, and filtered to leave a solid. Add 50 ml of ethanol, stir and beat at room temperature, wash the filter cake, and filter to obtain the target compound micafungin side chain 4-(5-(4-(pentyloxy)phenyl)isoxazol-3-yl)benzoic acid CAS number is 179162-55-1.

Thera. Category:Anti Fungal

Cas No.:179162-55-1

Synonyms: Micafungin Intermediate;4-[5-[4-(Pentyloxy)phenyl]-3-isoxazolyl]benzoic acid;4-(5-{4-[(Pent-1-yl)oxy]phenyl}isoxazol-3-yl)benzoicacid;Micafungin Intermediate 2;4-(5-(4-(pentyloxy)phenyl)isoxazol-3-yl)benzoic acid;4-(5-(4-(Pentyloxy)phenyl)isoxazol-3-yl)benzoic acid Micafungin InterMediate;4-[5-(4-Pentyloxy-phenyl)-isoxazol-2-yl]-benzoic acid

179162-55-1

Molecular Formula:C21H21NO4

Molecular Weight:351.39574

Purity: ≥99%

Packing: Export worthy packing

Material Safety Data Sheet: Available on request

Related Intermediate

Micafungin side chain :4-(5-(4-(pentyloxy)phenyl)isoxazol-3-yl)benzoic acid CAS number is 179162-55-1



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