(3R,4R)-3,4-dimethyl-4-(3-hydroxyphenyl)piperidine Used to Make Alvimopan 119193-19-0

(3R,4R)-3,4-dimethyl-4-(3-hydroxyphenyl)piperidine is used to make Alvimopan CAS number is 119193-19-0, molecular formula: C13H19NO, molecular weight: 205.3. In the reaction step of Alvimopan,( 57280523,3R,4R)-3,4-dimethyl-4-(3-hydroxyphenyl)piperidine was added to N-1 step of Alvimopan in the reaction to get the crude Alvimopan.The specific operation process is as follows:
(3R,4R)-3,4-dimethyl-4-(3-hydroxyphenyl)piperidine 30g,( 57280524,S)-2-methanesulfonylmethylphenylpropionyl-glycine isobutyl ester 55g, 150 ml of Diethylamine and 1500 ml of toluene were added to a three-necked flask, and the mixture was heated under reflux for 6 hours. After the reaction was completed, the mixture was cooled to room temperature, and then added with water (600 ml), and the organic layer was separated, dried over anhydrous sodium sulfate, filtered, and evaporated. Oily Ivoric isobutyl ester 34g. Add 34 g of Ivoric isobutyl ester to a 2000 ml three-necked flask, add 850 ml of ethanol and 100 ml of water, and add 210 ml of 1N sodium hydroxide solution dropwise with stirring at room temperature. After 20 minutes, the mixture was stirred at room temperature for 3 hours, concentrated under reduced pressure to remove ethanol. 200 ml of absolute ethanol was added, and 6N hydrochloric acid was added dropwise thereto at room temperature to pH 5.5, and a pale yellow solid was precipitated. The mixture was stirred at room temperature for 2 hours, and filtered to give a pale-yellow solid. After drying, 18.4 g of crude Alvimopan was obtained.

Thera. Category:DIGESTIVE SYSTEM AGENTS

Cas No.: 119193-19-0

Synonym:(+)-(3R,4R)-3,4-DIMETHYL-4-(3-HYDROXYPHENYL)PIPERIDINE;(+)-(3R,4R)-3,4-Dimethyl-4-(3-hydroxyphenyl)piperidine ,98%;(3R,4R)-3-(3,4-Dimethyl-4-piperidinyl)phenol;3-(3,4-diMethylpiperidin-4-yl)phenol;(+)-(3R,4R)-DiMethyl-4-(3-hydroxyphenyl)piperidine;(3R-cis)-3-(3,4-diMethyl-4- piperidinyl)phenol;3-[(3R,4R)-3,4-DiMethyl-4-piperidinyl]phenol;3-((3R,4R)-3,4-diMethylpiperidin-4-yl)phenol

Molecular Formula:C13H19NO

Molecular Weight:205.3

Assay: ≥98.%

Appearance: White Crystalline solid

Storage: normal

Packing:Export worthy packing

Material Safety Data Sheet:Available on request

Related intermediate:

1. Alvimopan phenylpropanoic acid methyl ester hydrochloride CAS 170098-28-9

2. (3R,4R)-3,4-dimethyl-4-(3-hydroxyphenyl)piperidine Cas 119193-19-0

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