Contact Supplier

Ms. Amy Cheng
Leave a messageUnit Price: | USD 1 / Kilogram |
---|---|
Payment Type: | T/T |
Incoterm: | CIF |
Min. Order: | 1 Kilogram |
Delivery Time: | 15 Days |
Basic Info
Model No.: 119193-19-0
Additional Info
Packaging: AS REQUIRED
Productivity: KGS
Brand: VOLSENCHEM
Transportation: Air
Place of Origin: CHINA
Supply Ability: TRUE MANUFACTURER
Certificate: ISO
Product Description
(3R,4R)-3,4-dimethyl-4-(3-hydroxyphenyl)piperidine is used to make Alvimopan CAS number is 119193-19-0, molecular formula: C13H19NO, molecular weight: 205.3. In the reaction step of Alvimopan,( 57280523,3R,4R)-3,4-dimethyl-4-(3-hydroxyphenyl)piperidine was added to N-1 step of Alvimopan in the reaction to get the crude Alvimopan.The specific operation process is as follows:
(3R,4R)-3,4-dimethyl-4-(3-hydroxyphenyl)piperidine 30g,( 57280524,S)-2-methanesulfonylmethylphenylpropionyl-glycine isobutyl ester 55g, 150 ml of Diethylamine and 1500 ml of toluene were added to a three-necked flask, and the mixture was heated under reflux for 6 hours. After the reaction was completed, the mixture was cooled to room temperature, and then added with water (600 ml), and the organic layer was separated, dried over anhydrous sodium sulfate, filtered, and evaporated. Oily Ivoric isobutyl ester 34g. Add 34 g of Ivoric isobutyl ester to a 2000 ml three-necked flask, add 850 ml of ethanol and 100 ml of water, and add 210 ml of 1N sodium hydroxide solution dropwise with stirring at room temperature. After 20 minutes, the mixture was stirred at room temperature for 3 hours, concentrated under reduced pressure to remove ethanol. 200 ml of absolute ethanol was added, and 6N hydrochloric acid was added dropwise thereto at room temperature to pH 5.5, and a pale yellow solid was precipitated. The mixture was stirred at room temperature for 2 hours, and filtered to give a pale-yellow solid. After drying, 18.4 g of crude Alvimopan was obtained.
Thera. Category:DIGESTIVE SYSTEM AGENTS
Cas No.: 119193-19-0
Synonym:(+)-(3R,4R)-3,4-DIMETHYL-4-(3-HYDROXYPHENYL)PIPERIDINE;(+)-(3R,4R)-3,4-Dimethyl-4-(3-hydroxyphenyl)piperidine ,98%;(3R,4R)-3-(3,4-Dimethyl-4-piperidinyl)phenol;3-(3,4-diMethylpiperidin-4-yl)phenol;(+)-(3R,4R)-DiMethyl-4-(3-hydroxyphenyl)piperidine;(3R-cis)-3-(3,4-diMethyl-4- piperidinyl)phenol;3-[(3R,4R)-3,4-DiMethyl-4-piperidinyl]phenol;3-((3R,4R)-3,4-diMethylpiperidin-4-yl)phenol
Molecular Formula:C13H19NO
Molecular Weight:205.3
Assay: ≥98.%
Appearance: White Crystalline solid
Storage: normal
Packing:Export worthy packing
Material Safety Data Sheet:Available on request
Related intermediate:
1. Alvimopan phenylpropanoic acid methyl ester hydrochloride CAS 170098-28-9
2. (3R,4R)-3,4-dimethyl-4-(3-hydroxyphenyl)piperidine Cas 119193-19-0
Looking for ideal Alvimopan Intermediates Cas 119193-19-0 Manufacturer & supplier ? We have a wide selection at great prices to help you get creative. All the Intermediates For Alvimopan Cas 119193-19-0 are quality guaranteed. We are China Origin Factory of CAS Number 119193-19-0. If you have any question, please feel free to contact us.
Product Categories : Other Chemicals
Hot Products