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Ms. Amy Cheng
Leave a messageUnit Price: | USD 1 / Kilogram |
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Payment Type: | T/T |
Incoterm: | CIF |
Min. Order: | 1 Kilogram |
Delivery Time: | 15 Days |
Basic Info
Model No.: 1280210-80-1
Additional Info
Packaging: AS REQUIRED
Productivity: KGS
Brand: VOLSENCHEM
Transportation: Air
Place of Origin: CHINA
Supply Ability: TRUE MANUFACTURER
Certificate: ISO
Product Description
Omarigliptin (MK-3102) intermediate has the chemical name of 2-(Methylsulfonyl)-2,4,5,6-tetrahydropyrrolo[3,4-c]pyrazole, CAS number is 1280210-80-1, molecular formula: C12H15N3O5S2, molecular weight: 345.39, his synthesis process is adding 3.3Kg benzenesulfonic acid to 14 L of ethyl acetate to dissolve, and circulate the frozen brine to 5 to 15℃; 2.85 Kg of 2-(methylsulfonyl)-2,4,5,6-tetrahydropyrrolo[3 , 4-C]pyrazole besylate was added to 14 L of ethyl acetate to dissolve, and added to the solution of benzenesulfonic acid and ethyl acetate at 5 to 15 ℃, stirred for 30 minutes, and then dehydrated to 25 ± 5℃ After stirring at for 16 hours, the solid was obtained by centrifugation. The solid was added to 17 L of ethyl acetate and stirred for 1.5 hours. After centrifugation, the solid was washed with 4 L of ethyl acetate. The wet product was dried at -0.08 MPa to -0.1 MPa, and vacuum dried at 40 ℃ for 8 hours. The yellow solid compound was 3.16 Kg. This pale yellow solid compound was the Omarigliptin (MK-3102) intermediate 2-(Methylsulfonyl)-2,4,5,6-tetrahydropyrrolo[3,4-c]pyrazole CAS 1280210-80-1.
Thera. Category:Anti Diabetes
Cas No.: 1280210-80-1
Synonym: 2-(Methylsulfonyl)-2,4,5,6-tetrahydropyrrolo[3,4-c]pyrazole;2-(Methylsulfonyl)-2,4,5,6-tetrahydropyrrolo[3,4-c]pyrazole benzenesulfonate;MK-3102 interMediate;2-(Methylsulfonyl)-2,4,5,6-tetrahydropyrrolo[3,4-c]pyrazol-5-iuM benzenesulfonate;2,4,5,6-Tetrahydro-2-(methylsulfonyl)pyrrolo[3,4-c]pyrazole benzenesulfonate;Omarigliptin inter. OG-2;MK-3102 intermediate3;2-Methanesulfonyl-2,4,5,6-tetrahydro-pyrrolo[3,4-c]pyrazole Benzenesulfonic acid salt
Molecular Formula:C12H15N3O5S2
Molecular Weight:345.39
Assay: ≥98.%
Appearance: White Crystalline solid
Storage: normal
Packing:Export worthy packing
Material Safety Data Sheet:Available on request
Related Intermediate:
1)N-[(2R,3S)-2-(2,5-difluorophenyl)tetrahydro-5-oxo-2H-pyran-3-yl]-CarbaMic acid 1,1-diMethylethyl ester 951127-25-6
2)2-(Methylsulfonyl)-2,4,5,6-tetrahydropyrrolo[3,4-c]pyrazole, CAS 1280210-80-1,
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Product Categories : Pharmaceutical Intermediates > Anti-Diabetes
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