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Taizhou Volsen Chemical Co., Ltd.
HomeProductsPharmaceutical IntermediatesAnti-Tumor/CancerEnasidenib Intermediate 2 CAS 1446507-38-5
Enasidenib Intermediate 2 CAS 1446507-38-5
  • Enasidenib Intermediate 2 CAS 1446507-38-5

Enasidenib Intermediate 2 CAS 1446507-38-5

    Unit Price: USD 1 / Gram
    Payment Type: T/T
    Incoterm: CIF
    Min. Order: 1 Gram
    Delivery Time: 15 Days

Basic Info

Model No.: 1446507-38-5

Additional Info

Packaging: As Quantity

Productivity: As Order


Transportation: Air

Place of Origin: CHINA

Supply Ability: IN STOCK

Product Description

Enasidenib intermediate 6-(6-(Trifluoromethyl)pyridin-2-yl)-1,3,5-triazine-2,4(1H,3H)-dione CAS 1446507-38-5, Molecular formula: C9H5F3N4O2, molecular weight: 258.1568096. His synthesis process is as below :1. 25 g of 6-trifluoromethylpyridine-2-carboxylic acid was dissolved in 300 mL of methanol, 23.3 g of sulfoxide was added dropwise, and the reaction was heated and refluxed for 12 h after the dropwise addition. The reaction solution was concentrated to dryness, a saturated sodium bicarbonate solution was added to adjust the pH, extracted with ethyl acetate, dried over anhydrous sodium sulfate, and concentrated to obtain methyl 6- (trifluoromethyl) -picolinate.2. Dissolve 13 g of biuret in 300 mL of ethylene glycol dimethyl ether, add 42 g of sodium hydride in portions, and heat and stir at 50 ° C for 1 h. 21.6 g of methyl 6- (trifluoromethyl) -picolinate was added, and the mixture was heated at 85 ° C for 16 hours. The reaction solution was poured into water, the pH was adjusted with concentrated hydrochloric acid, filtered, and the filter cake was dried to obtain 6-(6-(Trifluoromethyl)pyridin-2-yl)-1,3,5-triazine-2,4(1H,3H)-dione CAS 1446507-38-5.

Thera. Category:Anticancer

Cas No.:1446507-38-5

Synonyms:6-(6-(trifluoromethyl)pyridin-2-yl)-1,3,5-triazine-2,4(1H,3H)-dione;Enasidenib Intermediate 2




Assay: ≥99%

Packing:Export worthy packing

Material Safety Data Sheet:Available on request

Related Intermediates:

6- (trifluoromethyl) pyridine-2-carboxylic acid CAS131747-42-7

4-Amino-2-trifluoromethylpyridine CAS 147149-98-2

6-(6-(Trifluoromethyl)pyridin-2-yl)-1,3,5-triazine-2,4(1H,3H)-dione CAS 1446507-38-5

4-chloro-6-(6-(trifluoromethyl)pyridin-2-yl)-N-(2-(trifluoromethyl)pyridin-4-yl)-1,3,5-triazin-2-amine CAS 1446507-68-1

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Product Categories : Pharmaceutical Intermediates > Anti-Tumor/Cancer

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