Taizhou Volsen Chemical Co., Ltd.
HomeProductsPharmaceutical IntermediatesAnti-Psychotics4-Chloro-Benzo[b]thiophene For Making Brexpiprazole CAS 66490-33-3
4-Chloro-Benzo[b]thiophene For Making Brexpiprazole CAS 66490-33-3
  • 4-Chloro-Benzo[b]thiophene For Making Brexpiprazole CAS 66490-33-3

4-Chloro-Benzo[b]thiophene For Making Brexpiprazole CAS 66490-33-3

    Unit Price: USD 1 / Kilogram
    Incoterm: CIF
    Min. Order: 1 Kilogram
    Delivery Time: 15 Days

Basic Info

Model No.: 66490-33-3

Additional Info

Packaging: As required

Productivity: 10KG/M


Transportation: Air

Place of Origin: CHINA

Certificate: Technical Support

Product Description

4-chloro- Benzo[b]thiophene is intermediate of brexpiprazole CAS number 66490-33-3. We can also provide another compounds in the form of bromine. It is the primary intermediate of brexpiprazole, mainly for the synthesis of brexpiprazole high-level intermediate of 1 - (benzo [b] thiophen-7-yl) piperazine hydrochloride, we will referred it as piperazine hydrochloride salt. The conventional synthesis method is directly reacted 4-chlorobenzo [b] thiophene with piperazine to obtain piperazine hydrochloride, but since the substitution reaction is insufficient in the case where the chlorine atom in the 4-chlorobenzo [b] thiophene is not actively, easy to cause excessive impurities, which brings some difficulties to the post-processing and purification. So this method is not ideal. There is also a method in which put anhydrous piperazine reacted with BOC anhydride in methylene chloride to give N-BOC-piperazine and then coupled with 4-chlorobenzo [b] thiophene in the presence of catalyst BINAP and palladium acetate to give the corresponding compound and then react with concentrated hydrochloric acid to give the target compound piperazine hydrochloride CAS number 66490-33-3.

Thera. Category:Anti- Psychotics

Cas No.:66490-33-3

Synonyms: 4-chloro- Benzo[b]thiophene;Benzo[b]thiophene, 4-chloro-;4-Chlorobenzothiophene;Intermediate of Brexpiprazole

NW: 168.6433

M.W.: C8H5ClS


Assay: ≥99%

Packing:Export worthy packing

Material Safety Data Sheet:Available on request

Usage: Intermediate of Brexpiprazole

Looking for ideal Intermediate of Brexpiprazole 66490-33-3 Manufacturer & supplier ? We have a wide selection at great prices to help you get creative. All the CAS 66490-33-3 are quality guaranteed. We are China Origin Factory of CAS Number 66490-33-3. If you have any question, please feel free to contact us.

Product Categories : Pharmaceutical Intermediates > Anti-Psychotics

Email to this supplier
  • Amy ChengMs. Amy Cheng
  • Your message must be between 20-8000 characters

Related Products List